I studied medicine in Cambridge and Oxford, and following junior doctor posts on the English south coast, returned to Oxford to specialise in nephrology and general internal medicine. During my PhD Studentship (2010-2014) I applied bioinformatics and molecular biology to explore methods to identify disease causing genetic variants and translated lessons from the mammalian sequencing to protocols used to study human kidney disease genetics on a larger scale. I recently established my own group as a Principal Investigator in the Nuffield Department of Medicine, funded by the Medical Research Council and Kidney Research UK as a Professor David Kerr Clinician Scientist. My research aims to translate recent progress in human genetics into mechanistic insights in proteinuric and glomerular renal disease, using in vitro and in vivo models to explore cellular pathology. I continue to practice as an honorary consultant nephrologist, with a specialist interest in metabolic and genetic renal disease. Linking my academic and clinical roles I have established the first renal clinical genetics service in Oxford. I am local lead investigator for the NURTURE-CKD and NURTURE-NephroS clinical studies, and Staines Medical Research Fellow at Exeter College Oxford.